Treatment of skid-row alcoholics with disulfiram.

From skid row to Main Street: the Bowery series and the transformation of prostate cancer, 1951-1966.

Between 1951 and 1966, more than twelve hundred homeless, alcoholic men from New York's skid row were subjected to invasive medical procedures, including open perineal biopsy of the prostate gland. If positive for cancer, men typically underwent prostatectomy, surgical castration, and estrogen treatments. The Bowery series was meant to answer important questions about prostate cancer's diagnosi...

Homeless alcoholic women on skid row.

Studies of homeless alcoholic women remain rare. Women on Skid Row in New York City were sought out at the Women's Shelter for a study of homeless women alcoholics. The findings in this study of 31 homeless alcoholic women tend to confirm an earlier study by Garrett and Bahr in most respects. A major difference relates to the population's lack of homogeneity. A life-long pattern of marginality ...

Long-Term γ-Hydroxybutyric Acid (GHB) and Disulfiram Combination Therapy in GHB Treatment-Resistant Chronic Alcoholics

Leading Italian studies support the use of γ-hydroxybutyric acid (GHB), not only in the treatment of the alcohol withdrawal syndrome, but also in maintaining alcohol abstinence. GHB gives a better result than naltrexone and disulfiram in maintaining abstinence, and it has a better effect on craving than placebo or disulfiram. The problem is that about 30-40% of alcoholics are non-responders to ...

Treatment of alcoholic methadone-maintenance patients with disulfiram.

Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis

BACKGROUND Despite its success with compliant or supervised patients, disulfiram has been a controversial medication in the treatment of alcoholism. Often, study designs did not recognize a pivotal factor in disulfiram research, the importance of an open-label design. Our objectives are: (1) to analyze the efficacy and safety of disulfiram in RCTs in supporting abstinence and (2) to compare bli...